PTGIR: Products

PTGIR is a member of the G protein-coupled receptor family 1 and has been shown to be a receptor for prostacyclin (prostaglandin I2 or PGI2). Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to PTGIR.

Showing 1-9 out of 9 PTGIR Products

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BMY 45778


Non-prostanoid prostacyclin IP receptor partial agonist
1442 
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Iloprost


Prostacyclin (PGI2) analog
20382  
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Epoprostenol


Endogenous IP receptor agonist
29891  
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Selexipag


Selective prostacyclin IP1 receptor agonist
3351 
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Beraprost sodium


Potent prostacyclin IP receptor agonist
4180 
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Ro 1138452 hydrochloride


Selective prostacyclin IP receptor antagonist
4268 
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Treprostinil


Potent prostacyclin (PGI2) analog
5349 
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Human PTGIR (NP_000951) VersaClone cDNA

RDC0268 
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Mouse PTGIR (NP_032993) VersaClone cDNA

RDC0629 
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