PU.1/Spi-1: Products

PU.1 (Purine-rich nucleic acid binding protein 1; also 31 kDa transforming protein and SPI-1) is a member of the PU subfamily, ETS family of transcription factors. Although its predicted MW is 31 kDa, it appears to run anomalously high in SDS-PAGE at 40-45 kDa. PU.1 is a monomeric hematopoietic protein that regulates the differentiation of early myeloid and lymphoid progenitors. High PU.1 levels favor granulocyte and macrophage production, while low levels generate magakaryocytes, erythrocytes, T and B cells. Human PU.1 is 270 amino acids (aa) in length. It contains an N-terminal acidic/polyGln transactivation region (aa 34-99), a non-destabilizing PEST sequence (aa 117-165) and a C-terminal ETS DNA-binding domain (aa 170-253). PU.1 is phosphorylated on Ser146, allowing it to bind to Pip. Over aa 1-169, human PU.1 shares 88% aa identity with mouse PU.1.

Showing 1-6 out of 6 PU.1/Spi-1 Products

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Human PU.1/Spi-1 Antibody

Flow, ICC/IF, WBAF5870 
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Human PU.1/Spi-1 Antibody

Flow, WBMAB5870 
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Mouse PU.1/Spi-1 Antibody

ICC/IF, WBMAB7124 
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Mouse PU.1/Spi-1 Antibody

WBAF7124 
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Human PU.1/Spi-1 PE-conjugated Antibody

FlowIC5870P 
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Human PU.1/Spi-1 Fluorescein-conjugated Antibody

FlowIC5870F 
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