Poly(ADP-ribose) Polymerase Inhibitors: Products

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Showing 1-20 out of 20 Poly(ADP-ribose) Polymerase Inhibitors Products

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XAV 939


Potent tankyrase inhibitor
374829
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Nicotinamide


PARP-1 inhibitor
4106
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WIKI4


Potent tankyrase inhibitor
4855
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BSI 201


PARP-1 inhibitor
5817
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3-Aminobenzamide


PARP inhibitor
0788
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NU 1025


Potent PARP inhibitor
14011
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4-HQN


PARP inhibitor
2192
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DR 2313


PARP-1 and PARP-2 inhibitor
2496
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PJ 34 hydrochloride


Potent PARP inhibitor
32551
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BYK 204165


Selective PARP-1 inhibitor
37341
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BYK 49187


PARP-1 and PARP-2 inhibitor
3735
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UPF 1069


PARP-2 inhibitor
3736
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EB 47


Potent PARP-1 inhibitor
41403
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JW 55


Tankyrase inhibitor
45141
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TC-E 5001


Potent tankyrase inhibitor
5049
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ME 0328


Selective PARP-3 inhibitor
50542
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MN 64


Potent and selective tankyrase inhibitor
5084
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AZD 2461


Potent PARP inhibitor; orally bioavailable
6060
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Rucaparib camsylate


PARP inhibitor
6230
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OUL 35


Selective PARP-10 inhibitor
6344
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