Pygopus-2: Products

Pygopus-1 and -2 are nuclear transcription co-activators. Structurally they are characterized by an N-terminal homology domain and C-terminal PHD (plant homeodomain) finger Zn2+-binding domain. The PHD finger binds to legless/Bcl9, which in turn binds beta-catenin, a downstream mediator of Wnt signaling. This complex binds TCF/LEF DNA binding proteins. Formation of the quaternary complex is required for the activation of Wnt-responsive genes.

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Human Pygopus-2 Antibody

ICC/IF, IHC, SW, WBMAB3616 
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Human Pygopus-2 Antibody

IHC, WBAF3616 
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Human Pygopus-2 Biotinylated Antibody

WBBAF36161  
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