ROCK2: Products

ROCK2/II (Rho-associated protein kinase 2; also Rho-kinase alpha) is a member of the AGC serine/threonine protein kinase family. ROCK2 is a downstream target of activated RhoA. Its activation results in myosin phosphorylation with subsequent muscle contraction. Human ROCK2 is 1388 amino acids (aa) in length, and appears to be present as a dimer. It contains a protein kinase domain (aa 92-354), a coiled-coil region (aa 429-1131) and a zinc-finger region (aa 1260-1315). Two isoforms show an alternate start site at M686, and a three aa substitution for the N-terminal 444 amino acids. Over aa 641-846, human ROCK2 shares 94% and 96% aa identity with mouse and canine ROCK2, respectively.

Showing 1-14 out of 14 ROCK2 Products

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Y-27632 dihydrochloride


Selective p160ROCK inhibitor
1254107  
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Fasudil hydrochloride


Inhibitor of cyclic nucleotide dependent- and Rho-kinases
054110  
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Human/Mouse/Rat ROCK2 Antibody

WBAF4790 
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GSK 269962


Potent and selective ROCK inhibitor
40091  
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GSK 429286


Selective Rho-kinase (ROCK) inhibitor
3726 
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Glycyl-H 1152 dihydrochloride


Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
24854  
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OXA 06 dihydrochloride


Potent ROCK inhibitor
5182 
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AS 1892802


Potent ROCK inhibitor; orally bioavailable
4927 
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SR 3677 dihydrochloride


Potent, selective Rho-kinase (ROCK) inhibitor
36671  
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RKI 1447 dihydrochloride


Potent and selective ROCK inhibitor; antitumor
5061 
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SB 772077B dihydrochloride


Potent Rho-kinase inhibitor; vasodilator
4118 
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H 1152 dihydrochloride


Selective Rho-kinase (ROCK) inhibitor
24144  
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TC-S 7001


Potent and highly selective ROCK inhibitor; orally active
4961 
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HA 1100 hydrochloride


Cell-permeable, selective Rho-kinase inhibitor
24151  
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