Raf Kinase Inhibitors: Products

Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.

Showing 1-8 out of 8 Raf Kinase Inhibitors Products

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GW 5074


Potent, selective c-Raf1 kinase inhibitor
13817  
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SB 590885


Potent B-Raf inhibitor
26503  
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ZM 336372


Potent, selective c-Raf inhibitor
13213  
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KG 5


PDGFRbeta, B-Raf, c-Raf, FLT3 and KIT inhibitor
5260 
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GDC 0879


Potent B-Raf inhibitor
4453 
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Kobe 0065


H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
5475 
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AZ 628


Potent Raf kinase inhibitor
4836 
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ML 786 dihydrochloride


Potent Raf kinase inhibitor; orally bioavailable
5036 
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