Quick Order  

Welcome to Bio-Techne Quick Order!

Please enter a catalog number:
 
Enter CSV values, as SKU, QUANTITY.
 
View Your Cart

Simplified Shipping


We believe shipping should be simple. We charge a flat rate that depends on your currency and location.
  • No hidden charges
  • No additional charges for dry ice
  • No additional charges for multiple shipments
Choose a shipping destination
Albania

Algeria

Andorra

Angola

Antigua and Barbuda

Argentina

Armenia

Aruba

Australia

Austria

Azerbaijan

Bahamas

Bahrain

Bangladesh

Barbados

Belarus

Belgium

Belize

Benin

Bermuda

Bolivia

Bosnia and Herzegovina

Botswana

Brazil

Brunei

Bulgaria

Burkina Faso

Burundi

Cambodia

Cameroon

Canada

Cayman Islands

Central African Republic

Chad

Chile

China

Colombia

Costa Rica

Ivory Coast

Croatia

Cyprus

Czech Republic

Denmark

Djibouti

Dominica

Dominican Republic

Ecuador

Egypt

El Salvador

Equatorial Guinea

Eritrea

Estonia

Ethiopia

Falkland Islands

Fiji

Finland

France

French Polynesia

Gabon

Gambia

Georgia

Germany

Ghana

Gibraltar

Greece

Grenada

Guadeloupe

Guam

Guatemala

Guinea

Guinea-Bissau

Guyana

Haiti

Vatican

Honduras

Hong Kong S.A.R., China

Hungary

Iceland

India

Indonesia

Iraq

Ireland

Israel

Italy

Jamaica

Japan

Jordan

Kazakhstan

Kenya

South Korea

Kuwait

Kyrgyzstan

Latvia

Lebanon

Lesotho

Liberia

Liechtenstein

Lithuania

Luxembourg

Macedonia

Madagascar

Malawi

Malaysia

Mali

Malta

Marshall Islands

Mauritania

Mexico

Moldova

Monaco

Mongolia

Montenegro

Morocco

Mozambique

Myanmar

Namibia

Nepal

Netherlands

Netherlands Antilles

New Caledonia

New Zealand

Nicaragua

Niger

Nigeria

Northern Mariana Islands

Norway

Oman

Pakistan

Palau

Panama

Papua New Guinea

Paraguay

Peru

Philippines

Poland

Portugal

Puerto Rico

Qatar

Romania

Russia

Rwanda

Saint Kitts and Nevis

Saint Lucia

Saint Martin (French part)

Samoa

Saudi Arabia

Senegal

Serbia

Sierra Leone

Singapore

Slovakia

Slovenia

Solomon Islands

South Africa

Spain

Sri Lanka

Suriname

Swaziland

Sweden

Switzerland

Taiwan

Tanzania

Thailand

Togo

Trinidad and Tobago

Tunisia

Turkey

Uganda

Ukraine

United Arab Emirates

United Kingdom

United States

Uruguay

Uzbekistan

Venezuela

Vietnam

Yemen

Zambia

Zimbabwe

 

OR

Reelin: Products

Reelin is a 400 kDa modular glycoprotein that is critical in brain development and function. Reeler mutant mice have a Reelin deficiency and exhibit ataxia, tremors, and impaired motor coordination. Reelin consists of an N-terminal Reelin domain, eight domains that consist of an EGF-like repeat flanked by two subrepeats, and a C-terminal arginine-rich region. Reelin is cleaved into three fragments in vivo by metalloproteases. One (or central) fragment includes domains # 3 - 6 and retains many of the capabilities of the full length molecule.

In addition to being a protease substrate, Reelin itself has serine protease activity. Reelin forms disulfide-linked homodimers and large noncovalently-linked polymers. It utilizes Very Low Density Lipoprotein Receptors (VLDLR) and Apolipoprotein E (ApoE) R2 as receptors, through which it regulates several nervous system functions. Reelin is secreted by Cajal-Retzius cells and cerebellar granule cells during cortical plate development, and is required for proper neuronal migration and positioning.

The N-terminal domain binds integrin alpha-3/beta-1, leading to a disruption of neuronal-glial cell interactions and inhibition of neuronal migration. In the adult hippocampus, cortex, and amygdala, Reelin is required for dendrite growth and maturation, synaptic plasticity, and associative/contextual learning. In this capacity, it regulates the subunit composition of NMDA receptors and modulates NMDA currents, even though it does not interact directly with the receptor.Deficits in ApoE R2, Reelin, and ApoE function have been linked to several cognitive and mood disorders. Peripherally, Reelin is important in the development of neuromuscular junctions. But instead of utilizing the locally expressed ApoE R2 and VLDLR, this involvement requires the serine protease activity of Reelin.

Showing 1-2 out of 2
page of 1
Results Per Page

Mouse Reelin Antibody

1 Citation
Clonality: Polyclonal
Host: Goat IgG
Applications: WB, IHC
compare
(select up to 3 products from this page to compare)

AF3820

See All Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse Reelin Antibody

Clonality: Monoclonal
Host: Rat IgG2a Clone #397919
Applications: WB
compare
(select up to 3 products from this page to compare)

MAB3820

See All Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page