Filter Results
clear

By Category

By Common Name

clear

By Applications

clear

By Brand

SHB: Products

SH2 Homology Protein B (SHB) is a cytoplasmic adaptor protein that serves as a link between phosphotyrosine residues on multiple receptor tyrosine kinases and downstream signaling pathways. It is 509 amino acids (aa) in length with a predicted molecular mass of 55 kDa. A second, alternatively spliced human isoform has been identified that is 297 aa in length with a predicted molecular mass of 30 kDa. The mouse SHB ortholog shares 94% aa sequence identity with the human protein. SHB is ubiquitously expressed and binds tyrosine kinase receptors such as FGF R1, VEGF R2, and PDGF R following their activation. SHB also mediates T cell receptor signaling, as well as IRS1 and IRS2 signaling. It has been shown to contribute to the development and maintenance of hematopoietic stem cells by regulating cell cycle progression.

Showing 1-1 out of 1 SHB Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Human SHB Antibody

IHCAF7036 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page