SLC6A3/DAT1: Products

The dopamine transporter (DAT) is a 70 - 80 kDa member of the Na+-neurotransmitter symporter family of transmembrane (TM) proteins. DAT plays a crucial role in the synaptic clearance of dopamine (DA). It mediates the uptake of dopamine by the presynaptic terminal, thus limiting the strength of the dopamingeric response. One molecule of DA is accompanied by two Na+ and one Cl- ion. Molecules such as amphetamine both competitively inhibit DA uptake, and induce DA release through the DAT, increasing the rewarding property of DA.

The human dopamine transporter is a 620 amino acid (aa), 12 TM phosphoglycoprotein with an N- and C-terminal cytoplasmic domain. Human DAT exists as a disulfide-linked oligomer on the cell surface. Phosphorylation of the N-terminus (S7/12) promotes DA release. The C-terminus binds CaMKII, as well as Hic5, Pick1, and synuclein which regulate receptor trafficking and expression. There is an extended 71 aa extracellular (EC) loop between TM segments 3 and 4. Glycosylation at this site is necessary for oligomer expression on the cell membrane. The human 42 aa DAT C-terminus is 93% aa identical to the mouse DAT C-terminus. The human EC loop is also 93% aa identical to the rhesus monkey EC loop.

Showing 1-15 out of 15 SLC6A3/DAT1 Products

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Human/Mouse/Primate SLC6A3/DAT1 C-Terminus Antibody

IHC, WBPPS068 
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GBR 12909 dihydrochloride


Selective DA uptake inhibitor. Also sigma ligand
042111  
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Human/Primate SLC6A3/DAT1 Extracellular Loop 2 Antibody

IHC, WBPPS069 
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Nomifensine


Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
19921  
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Bupropion hydrochloride


Non-selective inhibitor of dopamine and noradrenalin transporters
28312  
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GBR 12783 dihydrochloride


Potent, selective dopamine uptake inhibitor
05132  
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BTCP maleate


Potent dopamine uptake inhibitor
0702 
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3-CPMT


Dopamine uptake inhibitor
0917 
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3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride


Potent dopamine uptake inhibitor
0918 
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GBR 12935 dihydrochloride


Selective dopamine uptake inhibitor
0514 
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JHW 007 hydrochloride


High affinity dopamine uptake inhibitor
43511  
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Threo-methylphenidate hydrochloride


Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant. Not for Sale in the USA. Restrictions apply. See special conditions on product page.
18122  
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GBR 13069 dihydrochloride


Potent dopamine uptake inhibitor
0420 
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Human IL-28 R alpha/IFN-lambda R1 NP_734464 VersaClone cDNA

RDC1082 
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Human SLC6A3/DAT1 (NP_001035) VersaClone cDNA

RDC1080 
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