SOD1/Cu-Zn SOD: Products

Superoxide Dismutases, originally identified as Indophenoloxidases (IPOs), are enzymes that catalyze the conversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Three mammalian isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SODs are typically soluble secreted or cytosolic proteins, but are also found in the mitochondria and extracellular matrix.

Any of three metals, manganese, iron, or copper, may be used in the active site of SOD and are indicative of cellular localization.MnSOD (SOD2) is found in the mitochondria of both prokaryotes and ukaryotes, whereas the cytosol of eukaryotes and prokaryotic organisms contains Cu/ZnSOD (SOD1) and FeSOD, respectively.

There have been several mutations identified in the Cu/ZnSOD (SOD1) gene in amyotrophic lateral sclerosis (ALS) patients, possibly suggesting a role for free radicals in this disease process. The mechanism of motor neuron degeneration that occurs in ALS, however, is unclear at this time. Several hypotheses have been explored for the role of mutant SOD1 and convincing evidence for the involvement of apoptosis has been presented, as well.

Showing 1-3 out of 3 SOD1/Cu-Zn SOD Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Human/Mouse SOD1/Cu-Zn SOD Antibody

SW, WBAF34181  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human SOD1/Cu-Zn SOD Antibody

ICC/IF, WBMAB34181  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse/Rat SOD1/Cu-Zn SOD Antibody

WBAF37872  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page