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SOST/Sclerostin: Products

SOST, also known as Sclerostin, is a Cerberus/DAN family BMP antagonist and is an important regulator of bone homeostasis. Inactivating mutations in the SOST gene can cause sclerosteosis and van Buchem disease. SOST is expressed by terminally differentiated cells embedded in mineralized matrix including osteocytes, hypertrophic and prehypertrophic chondrocytes, and tooth cementocytes. Its expression is induced by BMP-2, -4, and -6 and is inhibited by parathyroid hormone (PTH). Its downregulation in osteocytes by physical loading of bone contributes to the mechanical sensor function of osteocytes and the subsequent increase in bone growth. SOST binds to BMP-2, -4, -5, -6, and -7 and inhibits the osteogenic differentiation induced by these BMPs. It inhibits canonical Wnt signaling by binding to LRP-5 and LRP-6 and inhibiting their association with Frizzled receptors. SOST reduces the proliferation of mesenchymal stem cells (MSC) and induces MSC apoptosis. Circulating levels of SOST are elevated in pathologies with bone involvement including low bone mineral density, Paget’s disease, multiple myeloma, and prostate cancer with bone metastases. It is also elevated in advanced chronic kidney disease, alcoholic liver disease, type 2 diabetes, and patients with increased abdominal and gynoid fat.

Showing 1-18 out of 18 SOST/Sclerostin Products

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Human Magnetic Luminex Assay

LXSAHM7  
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Human Luminex Assay

LXSAH4  
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Mouse SOST/Sclerostin Antibody

IHC, WBAF158916  
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Mouse/Rat SOST/Sclerostin Quantikine ELISA Kit

ELISAMSST002  
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Recombinant Human SOST/Sclerostin Protein

 1406-ST3  
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Recombinant Human SOST/Sclerostin Protein, CF

 1406-ST/CF3  
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Human SOST/Sclerostin Quantikine ELISA Kit

ELISADSST00 
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Mouse SOST/Sclerostin Biotinylated Antibody

IHC, WBBAF15894  
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Recombinant Mouse SOST/Sclerostin Protein

 1589-ST2  
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Recombinant Mouse SOST/Sclerostin Protein, CF

 1589-ST/CF2  
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Human SOST/Sclerostin Antibody

ELISA(Cap), WBMAB14066  
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Human SOST/Sclerostin Antibody

WBAF1406 
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Mouse SOST/Sclerostin Antibody

WBMAB15892  
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Human SOST/Sclerostin Biotinylated Antibody

WBBAF14062  
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Human SOST/Sclerostin DuoSet ELISA

ELISADY1406 
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Human SOST/Sclerostin Biotinylated Antibody

BAM14061 
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Quantikine Immunoassay Control Set797 Human SOST/Sclerostin


For use with catalog number DSST00
CtrlQC159 
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Mouse SOST/Sclerostin DuoSet ELISA

ELISADY1589-05 
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