STAT3: Products

The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. They are characterized structurally by the presence of the Src homology 2 (SH2) domain, and a C-terminal tyrosine phosphorylation site. Upon ligand binding, they are recruited to the activated receptor, via their SH2 domains, to receptor-associated tyrosine kinases of the Janus kinase family (JAK). Once phosphorylated by JAK, STATS are free to hetero- or homo-dimerize, and translocate to the nucleus where they bind DNA to regulate gene transcription.

Showing 1-19 out of 19 STAT3 Products

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Human/Mouse/Rat STAT3 Antibody

Flow, ICC/IF, IP, WBMAB17992  
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Proteome Profiler Human Phospho-Kinase Array Kit


Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
ARY003B75  
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Human Phospho-STAT3 (Y705) Antibody

Flow, ICC/IF, WBAF46071  
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Human/Mouse/Rat STAT3 Antibody

ChIP, ICC/IF, IPAF17992  
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Stattic


Selective STAT3 inhibitor
27989  
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Human/Mouse STAT3 Antibody

Flow, ICC/IF, WBAF179911  
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Human/Mouse Phospho-STAT3 (Y705) DuoSet IC ELISA

ELISADYC4607B-23  
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Niclosamide


STAT3 inhibitor; also inhibits mTORC1 signaling
40791  
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Human Phospho-STAT3 (Y705) MAb (Clone 805435)

WBMAB4607 
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Human Phospho-STAT3 (S727) Antibody

WBAF4934 
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Human/Mouse/Rat STAT3 PE-conjugated Antibody

FlowIC1799P 
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Human Phospho-STAT3 (S727) Antibody

WBMAB4934 
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Human/Mouse/Rat STAT3 Fluorescein-conjugated Antibody

FlowIC1799F 
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NSC 74859


Selective STAT3 inhibitor
4655 
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Cucurbitacin I


Selective inhibitor of STAT3/JAK2 signaling
15714  
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Human/Mouse/Rat STAT3 NorthernLights™ NL557-conjugated Antibody

ICC/IFNL1799R 
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SD 1008


JAK2/STAT3 signaling pathway inhibitor
3035 
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Cryptotanshinone


STAT3 inhibitor. Also displays multiple other activities
3713 
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Human STAT3 (NP_644805) VersaClone cDNA

RDC1454 
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