STAT6: Products

Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the Jak/STAT signal transduction pathway and mediates cytokine signaling by IL-4. IL-4 activation leads to tyrosine phosphorylation and accumulation in the nucleus of STAT6 homo and heterodimers. STAT6 acts as a signal transducer in the cytoplasm and, upon phosphorylation at Y641, translocates to the nucleus and binds to the DNA consensus site TTCN4GAA. Knockout studies in mice suggest that STAT6 functions in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 transcriptional activation occurs by binding p100 and p160 class (NcoA1, Src-1) co-activators. Gene expression studies indicate that STAT6 mediates cell proliferation and anti-apoptotic effects of IL-4.

Showing 1-14 out of 14 STAT6 Products

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Human Phospho-STAT6 (Y641) Antibody


Recombinant Monoclonal Antibody.
ICC/IF, WBMAB3717 
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Phospho-STAT6 (Y641) Alexa Fluor® 647-conjugated Antibody


Recombinant Monoclonal Antibody.
FlowIC37173R 
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Proteome Profiler Human Phospho-Kinase Array Kit


Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
ARY003B75  
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Human Phospho-STAT6 (Y641) Antibody

Flow, SW, WBAF37172  
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Mouse STAT6 Antibody

WBMAB2169 
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Human/Mouse/Rat STAT6 aa 627-838 Antibody

Flow, WBAF2167 
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Human STAT6 Antibody

Flow, ICC/IF, WBMAB2167 
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Human/Mouse STAT6 Antibody

IP, WBPA-ST61  
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Human/Mouse STAT6 aa 342-640 Antibody

WBAF21671 
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Human Phospho-STAT6 (Y641) Antibody

WBMAB37171 
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Human STAT6 APC-conjugated Antibody

FlowIC2167A 
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Human Phospho-STAT6 Y641 Antibody

ICC/IFMAB37172 
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Human STAT6 PE-conjugated Antibody

FlowIC2167P 
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Human STAT6 (NP_003144) VersaClone cDNA

RDC1450 
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