SUMO1: Products

Human Small Ubiquitin-like Modifier 1 (SUMO1), also known as Sentrin, UBL1, and SMT3C, is synthesized as a 101 amino acid (aa) propeptide with a predicted molecular weight of 11.5 kDa. Human SUMO1 is the most unique of the four identified SUMO proteins and shares only 44%, 47%, and 41% aa sequence identity with SUMO2, SUMO3, and SUMO4, respectively. In contrast, human SUMO1 shares 100% aa sequence identity with the mouse ortholog. SUMOs are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed SUMOylation. All SUMO proteins share a conserved Ubiquitin domain and a C-terminal diglycine cleavage/attachment site. Following cleavage of a four aa C-terminal prosegment, the C-terminal glycine residue of SUMO1 is enzymatically attached to a lysine residue on a target protein. In humans, SUMO1 is conjugated to a variety of molecules in the presence of the SAE1/UBA2 SUMO-activating (E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating (E2) enzyme. In yeast, the SUMO-activating (E1) enzyme is Aos1/Uba2p. SUMOylation can occur without the requirement of a specific SUMO ligase (E3), where SUMO1 is transferred directly from UBE2I/Ubc9 to specific substrates. In Alzheimers disease models SUMO1 has been shown to influence the generation of Amyloid-beta peptide by promoting the accumulation of BACE-1. Covalent modification of Phosphatase and Tensin Homolog Deleted on Chromosome (PTEN) by SUMO1 is thought to regulate tumorigenesis by retaining PTEN at the plasma membrane, an effect that suppresses PI 3-Kinase/Akt-dependent tumor growth.

Showing 1-29 out of 29 SUMO1 Products

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Recombinant Human GST-SUMO1 Protein, CF

 UL-710 
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Recombinant Human SUMO1 Protein, CF

 UL-712 
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Recombinant Human SUMO1 AMC Protein, CF

 UL-551 
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Human/Mouse SUMO1 Antibody

WBAF3289 
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Human SUMO1 Antibody

IP, WBA-722 
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Recombinant Human SUMO1 Fluorescein Protein, CF

 UL-735 
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Human SUMO Pan Specific Antibody

WBA-714 
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Recombinant Human SUMO1 Vinyl Sulfone Protein, CF

 UL-7021  
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Recombinant Human His6-SUMO1 Protein, CF

 UL-715 
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Human SUMO1 Antibody

WBA-716 
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SUMO1 Conjugation Kit

K-7101  
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Recombinant Human SUMO1 Rhodamine Protein, CF

 UL-736 
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Recombinant Human SUMO1 Mutant K16R Protein, CF

 ULM-712 
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Recombinant Human SUMO1 Mutant K17R Protein, CF

 ULM-714 
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Recombinant Human SUMO1 Mutant K16R/K17R Protein, CF

 ULM-720 
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Recombinant Human SUMO1 Mutant K7R/K16R/K17R Protein, CF

 ULM-722 
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Recombinant Human His6-SUMO Protein Set (1, 2, 3)


Contains 100 ug each of rhHis6-SUMO1, rhHis6-SUMO2, and rhHis6-SUMO3
K-705 
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Recombinant Human SUMO1 Biotin Protein, CF

 UL-725 
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Recombinant Human SUMO Protein Set (1, 2, 3)


Contains 100 ug each of rhSUMO1, rhSUMO2, and rhSUMO3
K-700 
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Recombinant Human SUMO1 Mutant K7R/K17R Protein, CF

 ULM-718 
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Recombinant Human SUMO1 Aminoluciferin Protein, CF

 UL-704 
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Recombinant Human Methylated SUMO1 Protein, CF

 UL-720 
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Recombinant Human SUMO1 Agarose Protein, CF

 UL-740 
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Recombinant Human SUMO1 Mutant K7R/K16R Protein, CF

 ULM-716 
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Recombinant Human Pro-SUMO1 Protein, CF

 UL-700 
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Recombinant Human HA-SUMO1 Vinyl Sulfone Protein, CF

 UL-703 
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Recombinant Human His6-Pro-SUMO1 Protein, CF

 UL-705 
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Recombinant Human SUMO1 Mutant K7R Protein, CF

 ULM-710 
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Recombinant Human SUMO1 Mutant Protein Set


Contains 50 ug each of rhSUMO1 (Wild-type), rhSUMO1 K7R, rhSUMO1 K16R, rhSUMO1 K17R, rhSUMO1 K7R/K16R, rhSUMO1 K7R/K17R, rhSUMO1 K16R/K17R, and rhSUMO1 K7R/K16R/K17R
K-712 
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