SUMO2: Products

Human Small Ubiquitin-like Modifier 2 (SUMO2), also known as Sentrin2 and SMT3B is synthesized as a 95 amino acid (aa), propeptide with a predicted 11 kDa. SUMO2 contains a two aa C-terminal prosegment and an 18 aa N-terminal protein interacting region between aa 33-50. Human SUMO2 shares 100% aa sequence identity with mouse SUMO2. SUMO2 also has very high aa sequence identity with SUMO3 and SUMO4, 86% and 85%, respectively. SUMO2 shares only 44% aa sequence identity with SUMO1. SUMOs are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed SUMOylation. All SUMO proteins share a conserved Ubiquitin domain and a C-terminal diglycine cleavage/attachment site. Following prosegment cleavage, the C-terminal glycine residue of SUMO2 is enzymatically attached to a lysine residue on a target protein. In humans, SUMO2 is conjugated to a variety of molecules in the presence of the SAE1/UBA2 SUMO-activating (E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating (E2) enzyme. In yeast, the SUMO-activating (E1) enzyme is Aos1/Uba2p. Because of the high level of aa sequence identity most studies report effects of SUMO2/3. For example, post-translational addition of SUMO2/3 was shown to modulate the function of ARHGAP21, a RhoGAP protein known to be involved in cell migration. Other reports indicate that the SUMOylation with SUMO2/3, but not SUMO1, may represent an important mechanism to protect neurons during episodes of cerebral ischemia. However, studies suggest that SUMO2/3 expression is regulated in an isoform-specific manner since oxidative stress downregulated the transcription of SUMO3 but not SUMO2.

Showing 1-19 out of 19 SUMO2 Products

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Human SUMO2/3 Antibody

WBA-718 
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Recombinant Human HA-SUMO2 Vinyl Sulfone Protein, CF

 UL-7591  
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Human/Mouse SUMO2/3/4 Antibody

WBAF3020 
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Human SUMO Pan Specific Antibody

WBA-714 
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Recombinant Human SUMO2 Protein, CF

 UL-752 
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SUMO2 Conjugation Kit

K-7151  
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Recombinant Human SUMO2 AMC Protein, CF

 UL-758 
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Recombinant Human SUMO2 Agarose Protein, CF

 UL-7551  
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Recombinant Human SUMO2 Biotin Protein, CF

 UL-754 
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Recombinant Human His6-SUMO Protein Set (1, 2, 3)


Contains 100 ug each of rhHis6-SUMO1, rhHis6-SUMO2, and rhHis6-SUMO3
K-705 
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Recombinant Human Poly-SUMO2 Hydrolysis Resistant (3-8), CF

 ULN-220 
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Recombinant Human His6-SUMO2 Protein, CF

 UL-753 
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Recombinant Human SUMO2 Mutant K11R Protein, CF

 ULM-752 
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Recombinant Human His6-Pro-SUMO2 Protein, CF

 UL-751 
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Recombinant Human Pro-SUMO2 Protein, CF

 UL-750 
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Recombinant Human SUMO2 Rhodamine Protein, CF

 UL-757 
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Human SUMO2/3 Antibody

IPA-724 
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Recombinant Human SUMO Protein Set (1, 2, 3)


Contains 100 ug each of rhSUMO1, rhSUMO2, and rhSUMO3
K-700 
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Recombinant Human SUMO2 Fluorescein Protein, CF

 UL-756 
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