SUMO3: Products

Human Small Ubiquitin-like Modifier 3 (SUMO3), also known as SMT3A, is synthesized as a 103 amino acid (aa), propeptide with a predicted 11.5 kDa. SUMO3 contains a two aa C-terminal prosegment. Human SUMO3 shares 83% sequence identity with mouse SUMO3. SUMO3 also has high aa sequence homology to SUMO2 and SUMO4, 87% and 75%, respectively. SUMO3 shares only 47% sequence identity with SUMO1. SUMOs are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed SUMOylation. All SUMO proteins share a conserved Ubiquitin domain and a C-terminal diglycine cleavage/attachment site. Following prosegment cleavage, the C-terminal glycine residue of SUMO3 is enzymatically attached to a lysine residue on a target protein. In humans, SUMO3 is conjugated to a variety of molecules in the presence of the SAE1/UBA2 SUMO-activating (E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating (E2) enzyme. In yeast, the SUMO-activating (E1) enzyme is Aos1/Uba2p. Because of the high level of sequence homology most studies report effects of SUMO2/3. For example, addition of SUMO2/3 was shown to modulate the function of ARHGAP21, a RhoGAP protein known to be involved in cell migration. Other reports indicate that the conjugation by SUMO2/3, but not SUMO1, may represent an important mechanism to protect neurons during episodes of cerebral ischemia. However, studies suggest that SUMO2/3 expression is regulated in an isoform-specific manner since oxidative stress downregulated the transcription of SUMO3 but not SUMO2.

Showing 1-24 out of 24 SUMO3 Products

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Human SUMO3 Antibody


Recombinant Monoclonal Antibody.
ICC/IFMAB2959R 
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Human SUMO2/3 Antibody

WBA-718 
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Human/Mouse SUMO2/3/4 Antibody

WBAF3020 
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Human/Mouse SUMO3 Antibody

WBAF2959 
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SUMO3 Conjugation Kit

K-7201  
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Human SUMO3 Antibody

WBA-720 
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Human SUMO3 Antibody

ICC/IFMAB2959 
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Human SUMO Pan Specific Antibody

WBA-714 
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Recombinant Human SUMO3 AMC Protein, CF

 UL-768 
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Recombinant Human SUMO Protein Set (1, 2, 3)


Contains 100 ug each of rhSUMO1, rhSUMO2, and rhSUMO3
K-700 
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Recombinant Human SUMO3 Agarose Protein, CF

 UL-765 
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Recombinant Human Pro-SUMO3 Protein, CF

 UL-760 
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Recombinant Human SUMO3 Protein, CF

 UL-762 
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Recombinant Human His6-Pro-SUMO3 Protein, CF

 UL-761 
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Recombinant Human His6-SUMO3 Protein, CF

 UL-763 
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Recombinant Human SUMO3 Mutant K11R Protein, CF

 ULM-762 
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Recombinant Human SUMO3 Biotin Protein, CF

 UL-764 
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Recombinant Human SUMO3 Fluorescein Protein, CF

 UL-766 
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Recombinant Human Poly-SUMO3 Hydrolysis Resistant (3-8), CF

 ULN-320 
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Recombinant Human SUMO3 Rhodamine Protein, CF

 UL-767 
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Recombinant Human His6-SUMO Protein Set (1, 2, 3)


Contains 100 ug each of rhHis6-SUMO1, rhHis6-SUMO2, and rhHis6-SUMO3
K-705 
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Human SUMO2/3 Antibody

IPA-724 
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Recombinant Human HA-SUMO3 Vinyl Sulfone Protein, CF

 UL-769 
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Human RNF4 Ubiquitin Ligase Kit - di-SUMO3 Substrate

K-220 
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