Secretase Inhibitors: Products

Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.

Showing 1-11 out of 11 Secretase Inhibitors Products

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DAPT


γ-secretase inhibitor
263438
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DBZ


γ-secretase inhibitor; inhibits Notch pathway
44893
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L-685,458


Potent and selective γ-secretase inhibitor
26275
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Compound W


γ-secretase inhibitor
26542
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JLK 6


Inhibitor of γ-secretase-mediated βAPP processing
2677
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BMS 299897


Potent γ-secretase inhibitor
28701
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MRK 560


γ-secretase inhibitor; attenuates amyloid plaque deposition
40003
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Begacestat


γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
4283
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Flurizan


γ-secretase inhibitor; lowers Aβ42 levels in vitro
4495
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PF 3084014 hydrobromide


Potent γ-secretase inhibitor
5751
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Compound E


γ-secretase inhibitor; induces neuronal differentiation
6476
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