Secretase Inhibitors: Products

Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.

Showing 1-10 out of 10 Secretase Inhibitors Products

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DAPT


gamma-secretase inhibitor
263424  
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L-685,458


Potent and selective gamma-secretase inhibitor
26271  
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MRK 560


gamma-secretase inhibitor; attenuates amyloid plaque deposition
40002  
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DBZ


gamma-secretase inhibitor; inhibits Notch pathway
44892  
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Begacestat


gamma-secretase inhibitor; lowers Abeta40 and Abeta42 levels
4283 
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Flurizan


gamma-secretase inhibitor; lowers Abeta42 levels in vitro
4495 
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Compound W


gamma-secretase inhibitor
26541  
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BMS 299897


Potent gamma-secretase inhibitor
2870 
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JLK 6


Inhibitor of gamma-secretase-mediated betaAPP processing
2677 
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PF 3084014 hydrobromide


Potent gamma-secretase inhibitor
5751 
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