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Serpin E1/PAI-1: Products

Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.

Showing 1-6 out of 6 Serpin E1/PAI-1 Products

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Human Serpin E1/PAI-1 Quantikine ELISA Kit

ELISADSE10018  
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Human Serpin E1/PAI-1 DuoSet ELISA

ELISADY17867  
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Human Total Serpin E1/PAI-1 Quantikine ELISA Kit

ELISADTSE100 
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Quantikine Immunoassay Control Set 778 Human Serpin E1/PAI-1


For use with catalog number DSE100
CtrlQC157 
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Mouse Serpin E1/PAI-1 DuoSet ELISA

ELISADY3828-051  
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Quantikine Immunoassay Control Set 822 Human Total PAI-1


For use with catalog number DTSE100
CtrlQC209 
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