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Serpin E1/PAI-1: Products

Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.

Showing 1-7 out of 7 Serpin E1/PAI-1 Products

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Human Magnetic Luminex Assay

LXSAHM17  
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Mouse Magnetic Luminex Assay

LXSAMSM5  
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Human Luminex Assay

LXSAH5  
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Human Serpin E1/PAI-1 Luminex Performance Assay


Fluorokine MAP for use in the Obesity Panel
LOB17863  
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Human Serpin E1/PAI-1 Magnetic Luminex Performance Assay

LOBM1786 
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Human Serpin E1/PAI-1 Luminex Performance Assay

LUCB1786 
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Human Serpin E1/PAI-1 Magnetic Luminex Performance Assay

LUCBM1786 
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