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Serpin E1/PAI-1: Products

Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis, and obesity. Serpin E1 can promote clot formation, arterial re-endothelialization, and neointima formation while protecting against vascular intima thickening. It binds Vitronectin and inhibits vascular smooth muscle cell and endothelial cell adhesion, proliferation, and motility. Serpin E1 binds and induces the LRP-dependent internalization of cell surface complexes containing uPA, uPAR, and Integrin alpha V beta 3. Serpin E1 secretion is upregulated during inflammation, physical injury, and exposure to Angiotensin II.

Showing 1-11 out of 11 Serpin E1/PAI-1 Products

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Proteome Profiler Human Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
ARY005B99  
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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B6  
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Proteome Profiler Human Angiogenesis Array Kit


Contains 4 membranes - each spotted in duplicate with 55 different cytokine antibodies
ARY00759  
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Proteome Profiler Mouse XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
ARY0283  
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Proteome Profiler Mouse Angiogenesis Array Kit


Contains 4 membranes - each spotted in duplicate with 53 different cytokine antibodies
ARY01521  
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Proteome Profiler Mouse Adipokine Array Kit


Contains 4 membranes - each spotted in duplicate with 38 different obesity-related antibodies
ARY0135  
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY0261  
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Proteome Profiler Human Adipokine Array Kit


Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
ARY0241  
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Proteome Profiler Human Protease/Protease Inhibitor Array


Contains 4 membranes-2 spotted in duplicate with antibodies against 34 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
ARY0251  
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Proteome Profiler Rat Adipokine Array Kit


Contains 4 membranes - each spotted in duplicate with 30 different obesity-related antibodies
ARY016 
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Proteome Profiler Human Protease Inhibitor Array Kit


Contains 4 membranes - each spotted in duplicate with 32 different protease inhibitor antibodies
ARY023 
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