Siglec-1/CD169: Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

Showing 1-13 out of 13 Siglec-1/CD169 Products

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Human Siglec-1/CD169 Antibody

B/N, WBAF5197 
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Mouse Siglec-1/CD169 Antibody

Flow, WBMAB5610 
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Mouse Siglec-1/CD169 Antibody

B/N, WBAF5610 
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Recombinant Human Siglec-1 Protein, CF

 5197-SL 
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Human Siglec-1/CD169 Alexa Fluor® 488-conjugated Antibody


Recombinant Monoclonal Antibody.
FlowFAB5197G 
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Mouse Siglec‑1/CD169 Biotinylated Antibody

WBBAF5610 
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Human Siglec-1/CD169 PE-conjugated Antibody


Recombinant Monoclonal Antibody.
FlowFAB5197P 
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Human Siglec-1/CD169 APC-conjugated Antibody


Recombinant Monoclonal Antibody.
FlowFAB5197A 
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Human Siglec-1/CD169 Antibody


Recombinant Monoclonal Antibody.
FlowMAB5197 
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Mouse Siglec-1/CD169 PE-conjugated Antibody

FlowFAB5610P 
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Human Siglec-1/CD169 Biotinylated Antibody

WBBAF5197 
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Human Siglec-1/CD169 (NP_075556) VersaClone cDNA

RDC1619 
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Recombinant Mouse Siglec-1 Fc Chimera Protein, CF

 5610-SL 
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