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Siglec-3/CD33: Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

Showing 1-10 out of 10 Siglec-3/CD33 Products

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Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF

 1137-SL 
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Human Siglec-3/CD33 Antibody

Flow, WBMAB1137 
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Mouse Siglec-3/CD33 Antibody

WBMAB2220 
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Mouse Siglec-3/CD33 Biotinylated Antibody

WBBAF2220 
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Mouse Siglec-3/CD33 Antibody

WBAF2220 
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Human Siglec-3/CD33 Fluorescein-conjugated Antibody

FlowFAB1137F 
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Human Siglec-3/CD33 APC-conjugated Antibody

FlowFAB1137A 
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Human Siglec-3/CD33 PE-conjugated Antibody

FlowFAB1137P 
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Human Siglec-3/CD33 (NP_001763) VersaClone cDNA

RDC1477 
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Proteome Profiler Human Phospho-Immunoreceptor Array Kit


Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
ARY004B 
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