Sirtuin 1/SIRT1: Products

Sirtuin 1 (SIRT1) is an NAD+dependent class III histone deacetylase. It is a member of the sirtuin family of proteins, homologous to the yeast Sir2 protein. SIRT1 modulates intracellular activities through transcription regulation and functions in several separate cellular functions. SIRT1 deacetylates and inactivates tumor suppressor protein p53, a process regulated by Hypermethylated in Cancer 1 (HIC1) protein to allow cells to bypass apoptosis and survive DNA damage. The level of SIRT1 is significantly elevated in mouse and human prostate cancer. SIRT1 promotes vascular relaxation by activating endothelial nitric oxide synthase. SIRT1 also protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappa b signaling.

Showing 1-9 out of 9 Sirtuin 1/SIRT1 Products

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EX 527


Selective SIRT1 inhibitor
278019  
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Human Sirtuin 1/SIRT1 Antibody

Flow, WBAF7714 
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Human Sirtuin 1/SIRT1 Antibody

Flow, ICC/IFMAB7714 
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Resveratrol


Cyclooxygenase inhibitor
14187  
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Recombinant Human Sirtuin 1/SIRT1 Protein, CF

 7714-DA1  
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Salermide


SIRT1 and SIRT2 inhibitor
4127 
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YK 3-237


SIRT1 activator
5667 
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Honokiol


Blocks NF-kappaB activation; also anti-inflammatory and antioxidant
4590 
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Splitomicin


Sir2p inhibitor
15422  
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