Sirtuin 1/SIRT1: Products

Sirtuin 1 (SIRT1) is an NAD+dependent class III histone deacetylase. It is a member of the sirtuin family of proteins, homologous to the yeast Sir2 protein. SIRT1 modulates intracellular activities through transcription regulation and functions in several separate cellular functions. SIRT1 deacetylates and inactivates tumor suppressor protein p53, a process regulated by Hypermethylated in Cancer 1 (HIC1) protein to allow cells to bypass apoptosis and survive DNA damage. The level of SIRT1 is significantly elevated in mouse and human prostate cancer. SIRT1 promotes vascular relaxation by activating endothelial nitric oxide synthase. SIRT1 also protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappa b signaling.

Showing 1-16 out of 16 Sirtuin 1/SIRT1 Products

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Resveratrol


Cyclooxygenase inhibitor
14187
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Human Sirtuin 1/SIRT1 Antibody

CyTOF-ready, Flow, KO, WBAF7714 
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Human Sirtuin 1/SIRT1 Antibody

CyTOF-ready, Flow, ICC/IFMAB7714 
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EX 527


Selective SIRT1 inhibitor
278025
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Honokiol


Blocks NF-κB activation; also anti-inflammatory and antioxidant
45901
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Recombinant Human Sirtuin 1/SIRT1 Protein, CF

Enzyme Activity7714-DA1  
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Splitomicin


Sir2p inhibitor
15422
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Salermide


SIRT1 and SIRT2 inhibitor
4127
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YK 3-237


SIRT1 activator
5667
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Human Sirtuin 1/SIRT1 Alexa Fluor® 488-conjugated Antibody

FlowIC7714G 
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Human Sirtuin 1/SIRT1 Alexa Fluor® 700-conjugated Antibody

FlowIC7714N 
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Human Sirtuin 1/SIRT1 Alexa Fluor® 647-conjugated Antibody

FlowIC7714R 
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Human Sirtuin 1/SIRT1 Alexa Fluor® 750-conjugated Antibody

FlowIC7714S 
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Human Sirtuin 1/SIRT1 Alexa Fluor® 594-conjugated Antibody

FlowIC7714T 
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Human Sirtuin 1/SIRT1 Alexa Fluor® 350-conjugated Antibody

FlowIC7714U 
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Human Sirtuin 1/SIRT1 Alexa Fluor® 405-conjugated Antibody

FlowIC7714V 
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