Synthetic Metalloprotease Inhibitors: Products

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

Showing 1-22 out of 22 Synthetic Metalloprotease Inhibitors Products

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GI 254023X


Selective ADAM10 metalloprotease inhibitor
39954  
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GM 6001


Broad spectrum MMP inhibitor
29833  
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Doxycycline hyclate


Broad-spectrum MMP inhibitor; tetracycline derivative
40901  
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Batimastat


Potent, broad spectrum MMP inhibitor
296119  
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WAY 170523


Potent and selective inhibitor of MMP-13
2633 
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Minocycline hydrochloride


Antibiotic. Displays neuroprotective effects
32682  
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Marimastat


Broad spectrum MMP inhibitor
263110  
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NSC 405020


Inhibitor of MT1-MMP; antitumor
49021  
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CL 82198 hydrochloride


Selective inhibitor of MMP-13
26321  
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CP 471474


Broad spectrum MMP inhibitor
37802  
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UK 383367


Potent and selective BMP-1 (PCP) inhibitor
4188 
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UK 356618


Potent and selective MMP-3 inhibitor
41871  
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ARP 101


Inhibitor of MMP-2
26222  
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PD 166793


Broad spectrum MMP inhibitor
2520 
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Bestatin, CF


An aminopeptidase inhibitor and leukotriene A4 hydrolase inhibitor
EI0051  
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ARP 100


Selective inhibitor of MMP-2
26212  
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UK 370106


Highly selective MMP-3 and MMP-12 inhibitor
29001  
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ONO 4817


Broad spectrum MMP inhibitor
2628 
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Ro 32-3555


Potent, collagenase-selective MMP inhibitor
29161  
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SD 2590 hydrochloride


Potent MMP inhibitor
4775 
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TMI 1


Adam 17 (TACE) and MMP inhibitor; orally bioavailable
5960 
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Phosphoramidon, CF


A thermolysin-like metalloprotease inhibitor
EI006 
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