TGF-beta RI/ALK-5: Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

Showing 1-22 out of 22 TGF-beta RI/ALK-5 Products

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SB 431542


Potent, selective inhibitor of TGF-betaRI, ALK4 and ALK7
1614135  
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A 83-01


Selective inhibitor of TGF-betaRI, ALK4 and ALK7
293927  
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Human TGF-beta  RI/ALK-5 Antibody

ICC/IF, WBAF30252  
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RepSox


Potent and selective inhibitor of TGF-betaRI
37423  
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Human/Mouse TGF-beta  RI/ALK-5 Antibody

WBMAB58713  
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Recombinant Human TGF-beta RI/ALK-5 Fc Chimera Protein, CF

 3025-BR 
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Mouse TGF-beta  RI/ALK-5 APC-conjugated Antibody

FlowFAB5871A1  
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SD 208


Potent ATP-competitive TGF-betaRI inhibitor
32692  
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SB 505124


Selective inhibitor of TGF-betaRI, ALK4 and ALK7
32632  
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Mouse TGF-beta  RI/ALK-5 PE-conjugated Antibody

FlowFAB5871P 
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LY 364947


Selective inhibitor of TGF-betaRI
27188  
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Mouse TGF-beta  RI/ALK-5 Antibody

WBAF5871  
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Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera Protein, CF

 587-RI2  
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Mouse TGF-beta  RI/ALK-5 Antibody

WBMAB5871  
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Mouse TGF-beta  RI/ALK‑5 Biotinylated Antibody

WBBAF5871  
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D 4476


Selective CK1 inhibitor. Also inhibits TGF-betaRI
29024  
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SB 525334


Selective inhibitor of TGF-betaRI
32115  
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Human TGF-beta  RI/ALK-5 Biotinylated Antibody

WBBAF3025 
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GW 788388


Potent and selective inhibitor of TGF-betaRI
32642  
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R 268712


Potent and selective inhibitor of TGF-betaRI
5288 
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Human TGF-beta RI/ALK-5 (NP_004603) VersaClone cDNA

RDC1294 
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Mouse TGF-beta RI/ALK-5 (NP_033396) VersaClone cDNA

RDC0709 
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