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TGF-beta 1: Products

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

Showing 1-43 out of 43 TGF-beta 1 Products

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 240-B258  
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 240-B/CF258  
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DB100B138  
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MB100B92  
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B/N, ELISA(Cap), ICC/IF, IHC, WBMAB183568  
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 7666-MB/CF18  
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 7666-MB18  
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 100-B22  
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 100-B/CF22  
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B/N, ELISA(Cap), Flow, IHC, WBMAB24043  
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DY24037  
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DY167931  
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B/N, WBAB-100-NA30  
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 101-B19  
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 101-B1/CF9  
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 299-LT7  
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B/N, WBAF-101-NA18  
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ELISA(Det), WBBAF24013  
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 299-LT/CF7  
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 7754-BH 
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 7754-BH/CF 
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NFTG09  
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FlowIC240P5  
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WBMAB24015  
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LTGM100 
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B/N, WBAB-101-NA1  
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FlowIC1835P2  
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 240-GMP 
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Contains 4 membranes - each spotted in duplicate with 55 different cytokine antibodies
ARY00737  
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FlowIC1835A 
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FlowIC240A1  
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Supplied as ready-to-use 5 ug protein balls
 PRD240 
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FlowIC240F1  
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FCST17 
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FCSTM17 
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LTG100 
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FlowIC1835N 
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 ACFP240 
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EL2461  
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FlowMAB7666 
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SEL2461  
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 8617-B1/CF 
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 8617-B1 
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