TGF-beta RI/ALK-5: Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

Showing 1-8 out of 8 TGF-beta RI/ALK-5 Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 
ICC/IF, WBAF30252  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
WBMAB58713  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
FlowFAB5871A 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
FlowFAB5871P 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
WBAF5871  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
WBMAB5871  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
WBBAF5871  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
WBBAF3025 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page