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TGF-beta RI/ALK-5: Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.
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Human TGF‑ beta  RI/ALK‑5 Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: ICC/IF, WB
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AF3025

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Human TGF‑ beta  RI/ALK‑5 Antibody Western Blot
Human TGF‑ beta  RI/ALK‑5 Antibody Immunocytochemistry

Human/Mouse TGF‑ beta  RI/ALK‑5 Antibody

Clonality: Monoclonal
Host: Rat IgG2a Clone #141231
Applications: WB
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MAB5871

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Mouse TGF‑ beta  RI/ALK‑5 Antibody

Clonality: Monoclonal
Host: Rat IgG2a Clone #141229
Applications: WB
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MAB587

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Mouse TGF‑ beta  RI/ALK‑5 Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB
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AF587

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Mouse TGF-beta  RI/ALK‑5 Biotinylated Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB
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BAF587

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Mouse TGF‑ beta  RI/ALK‑5 APC‑conjugated Antibody

Clonality: Monoclonal
Host: Rat IgG2a Clone #141231
Applications: Flow
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FAB5871A

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Mouse TGF‑ beta  RI/ALK‑5 APC‑conjugated Antibody Flow Cytometry

Mouse TGF‑ beta  RI/ALK‑5 PE‑conjugated Antibody

Clonality: Monoclonal
Host: Rat IgG2a Clone #141231
Applications: Flow
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FAB5871P

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Mouse TGF‑ beta  RI/ALK‑5 PE‑conjugated Antibody Flow Cytometry

Human TGF‑ beta  RI/ALK‑5 Biotinylated Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB
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BAF3025

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