TIGIT: Products

TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3, Vsig9,  and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 on dendritic cells (DC) and endothelium. Binding of TIGIT by DC induces IL-10 release and inhibits IL-12 production. Ligation of TIGIT on T cells downregulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. CD155 and Nectin-2 also interact with DNAM-1/CD226 and CD96/Tactile, and TIGIT binding to CD155 can antagonize the effects of DNAM-1. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses, while mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges.

Showing 1-13 out of 13 TIGIT Products

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Recombinant Human TIGIT Fc Chimera Protein, CF

 7898-TG1  
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Human TIGIT Antibody

FlowMAB7898 
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Human TIGIT APC-conjugated Antibody

FlowFAB7898A1  
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Recombinant Mouse TIGIT Fc Chimera Protein, CF

 7267-TG 
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Human TIGIT PE-conjugated Antibody

FlowFAB7898P 
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Mouse TIGIT APC-conjugated Antibody

FlowFAB7267A2  
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Human TIGIT Alexa Fluor® 700-conjugated Antibody

FlowFAB7898N 
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Mouse TIGIT Antibody

FlowAF7267 
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Mouse TIGIT Alexa Fluor® 488-conjugated Antibody

FlowFAB7267G 
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Human TIGIT PerCP-conjugated Antibody

FlowFAB7898C 
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Mouse TIGIT (NP_001139797) VersaClone cDNA

RDC1433 
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Cynomolgus Monkey TIGIT (XP_005548157) VersaClone cDNA

RDC1568 
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Human TIGIT (NP_776160) VersaClone cDNA

RDC1417 
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