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TIM-3: Products

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.

Showing 1-4 out of 4 TIM-3 Products

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Human TIM-3 PE-conjugated Antibody


Clone 344823 was used by HLDA to establish CD designation
FlowFAB2365P24  
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Human TIM-3 Antibody

CyTOF-ready, Flow, WBAF236514  
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Human TIM-3 APC-conjugated Antibody


Clone 344823 was used by HLDA to establish CD designation
FlowFAB2365A10  
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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B22  
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