TNF-alpha: Products

TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. It is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. Cell surface trimeric TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. Shedding of membrane bound TNF-alpha by TACE (ADAM17) releases the bioactive cytokine. TNF-alpha binds TNF RI and TNF RII and induces apoptotic signaling through the death domain of TNF RI.

Showing 1-8 out of 8 TNF-alpha Products

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SEL4102  
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EL4101  
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SEL690 
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SEL1070 
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SEL510 
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SEL1507 
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SEL210 
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SEL1814 
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