TNF-alpha: Products

TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. It is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. Cell surface trimeric TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. Shedding of membrane bound TNF-alpha by TACE (ADAM17) releases the bioactive cytokine. TNF-alpha binds TNF RI and TNF RII and induces apoptotic signaling through the death domain of TNF RI.

Showing 1-34 out of 34 TNF-alpha Products

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 210-TA/CF267  
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 210-TA267  
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 410-MT/CF130  
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 410-MT130  
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 510-RT35  
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 510-RT/CF35  
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 210-GMP 
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 AFL210 
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 690-PT/CF5  
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 690-PT5  
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 410-TRNC2  
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 410-TRNC/CF2  
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 BT210 
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 BT210/CF 
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 2279-BT3  
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 1507-CT/CF2  
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 1507-CT2  
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 2279-BT/CF3  
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 1070-RM/CF1  
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 1070-RM1  
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 1814-ET1  
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 1814-ET/CF1  
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 5670-TG/CF 
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 5670-TG 
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 5035-TG/CF 
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 1011-CR/CF 
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 5035-TG 
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Mutant form with approximately 5-fold greater activity
 8599-TA/CF 
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 1011-CR 
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 AFL410 
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Mutant form with approximately 5-fold greater activity
 8599-TA 
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 2586-FT 
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 2586-FT/CF 
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 1012-PS 
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