TRPM8: Products

TRPM8 functions as a cold receptor in sensory neurons but is also expressed in tissues not exposed to ambient temperatures, as well as in cancer tissues. TRPM8 is expressed in prostate and in most in prostate tumors. TRPM8 is also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors. There are two shorter splice variants of TRPM8, termed short TRPM8a and short TRPM8ß. Both variants are in a closed configuration with the C-terminal tail of the full-length TRPM8 channel, resulting in stabilization of its closed state and thus reducing both its cold sensitivity and activity. The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.

Showing 1-10 out of 10 TRPM8 Products

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WS 12


TRPM8 agonist; cooling agent
30401  
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AMTB hydrochloride


TRPM8 blocker
39894  
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Icilin


Activates a novel cold receptor. Cooling agent
15313  
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WS 3


TRPM8 agonist; cooling agent
2927 
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TC-I 2000


TRPM8 blocker
4632 
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M8 B hydrochloride


Potent and selective TRPM8 channel blocker
5324 
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RQ 00203078


Potent and selective TRPM8 antagonist; orally active
5388 
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TC-I 2014


Potent TRPM8 antagonist
5410 
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PF 05105679


Selective TRPM8 blocker
6003 
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Human TRPM8 (Q7Z2W7) VersaClone cDNA

RDC0188 
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