T Cell Differentiation Kits: Products

CD4+ T cells can differentiate into T helper (Th)1, Th2, Th17, and Regulatory T (Treg) cells by exposure to various cytokines and cellular interactions that induce expression of specific sets of transcription factors. Differentiation into Th1 cells is promoted through IL-12 and IFN-gamma. These cells are characterized by their secretion of IFN-gamma, IL-10, and TNF-alpha. Differentiation into Th2 cells is promoted by IL-4 in combination with either IL-2, IL-7, or TSLP. through IL-12 and IFN-gamma. These cells are characterized by their secretion of IFN-gamma, IL-10, and TNF-alpha. Th2 cells secrete IL-4, IL-5, IL-9, IL-13, and IL17E/IL-25. Differentiation into the Th17 lineage is promoted by cytokines such as TGF-beta and IL-6, while their survival and expansion are dependent on IL-21 and IL-23. Th17 cells secrete TNF-alpha, IL-6, IL-9, IL-17A, IL-17F, IL-21, IL-22, and (human) IL-26/AK155. The ability to differentiate CD4+ T cells ex vivo into Th1, Th2, Th17, or Treg cells is valuable to researchers who require specific T helper cell subsets for downstream applications, including studies for cell therapy and cancer immunotherapy.

Showing 1-3 out of 3 Th2 Cell Kits Products

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CellXVivo Human Th2 Cell Differentiation Kit

CDK002 
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Human Th2 Cell Multi-Color Flow Cytometry Kit


Contains conjugated antibodies to CD3-PerCP (Clone UCHT1), IL-4-Fluorescein (Clone 3007), STAT6-APC (Clone 253906), and IL-4 R-PE (Clone 25463)
FMC011 
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Mouse Th2 Cell Multi-Color Flow Cytometry Kit


Contains conjugated antibodies to CD4-PerCP (Clone GK1.5), IL-4 R (Goat IgG) Fluorescein, STAT6-APC (Clone 253906), and IL-5-PE (Clone TRFK5)
FMC012 
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