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Tie-1: Products

Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). It is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.

Human Tie-1 cDNA encodes a 1138 amino acid (aa) residue precursor protein with a 24 residue putative signal peptide, a 735 residue extracellular domain and a 354 residue cytoplasmic domain. Ligands which bind and activate Tie-1 have not been identified. Based on gene targeting studies, the in vivo functions of Tie-1 have been shown to be related to endothelial cell differentiation and the maintenance of integrity of the endothelium.

Showing 1-12 out of 12 Tie-1 Products

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Human Magnetic Luminex Assay

LXSAHM8  
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Build your own with our Luminex Assay Customization Tool.

Human Luminex Assay

LXSAH4  
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Build your own with our Luminex Assay Customization Tool.

Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B96  
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Human Tie-1 Antibody

Flow, IHC, WBAF6195  
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Human Tie-1 Antibody

ICC/IF, IHC, WBMAB6191  
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Recombinant Human Tie-1 Fc Chimera Protein, CF

 619-TI1  
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Human Tie-1 Biotinylated Antibody

WBBAF684 
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Human Tie-1 DuoSet ELISA

ELISADY59071  
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Human Tie-1 PE-conjugated Antibody

FlowFAB619P 
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Human Tie-2 (AAA61139) VersaClone cDNA

RDC1054 
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Human Tie-1 (NP_005415) VersaClone cDNA

RDC0592 
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Proteome Profiler Mouse Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
ARY0147  
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