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Tie-2: Products

Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.

Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

Showing 1-34 out of 34 Tie-2 Products

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Human Magnetic Luminex Assay

LXSAHM7  
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Human Luminex Assay

LXSAH4  
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Human Tie-2 Antibody

B/N, IHC, SW, WBAF31318  
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Recombinant Human Tie-2 Fc Chimera Protein, CF

 313-TI10  
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Human Tie-2 Quantikine ELISA Kit

ELISADTE20018  
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Human Tie-2 PE-conjugated Antibody

FlowFAB3131P8  
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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B96  
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Human/Mouse Phospho-Tie-2 (Y992) Antibody

Flow, WBAF27203  
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Mouse/Rat Tie-2 Antibody

B/N, WBAF7626  
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Human Tie-2 DuoSet ELISA

ELISADY51598  
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Human Tie-2 APC-conjugated Antibody

FlowFAB3131A4  
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Human/Mouse Phospho-Tie-2 (Y1102/Y1100) Antibody

IHC, WBAF39091  
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Mouse Tie-2 Quantikine ELISA Kit

ELISAMTE2003  
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Human Tie-2 Antibody

Flow, WBMAB31314  
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Human Tie-2 Antibody

MAB31321  
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Recombinant Mouse Tie-2 Fc Chimera Protein, CF

 762-T21  
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Human Tie-2 Antibody

WBMAB3133  
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Zebrafish Tie-2 Antibody

B/N, IHC, WBAF928 
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Zebrafish Tie-2 Antibody

B/N, WBMAB9281  
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Human Tie-2 Biotinylated Antibody

WBBAF3131  
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Human Phospho-Tie-2 DuoSet IC ELISA

ELISADYC2720-2 
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Recombinant Rat Tie-2 Fc Chimera Protein, CF

 3874-T2 
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Human Tie-2 Biotinylated Antibody

BAM33131  
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Human/Mouse Tie-2 Biotinylated Antibody

WBBAF762 
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Mouse Phospho-Tie-2 DuoSet IC ELISA

ELISADYC2816-2 
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Human Tie-2 Alexa Fluor® 700-conjugated Antibody

FlowFAB3131N 
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Human Tie-2 Alexa Fluor® 488-conjugated Antibody

FlowFAB3131G 
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Zebrafish Tie-2 Biotinylated Antibody

WBBAF928 
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XL 184


Potent VEGFR inhibitor; also inhibits other RTKs
5422 
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Mouse Tie-2 (NP_038718) VersaClone cDNA

RDC1298 
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Recombinant Zebrafish Tie-2 Fc Chimera Protein, CF

 928-T2 
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Quantikine Immunoassay Control Set 832 for Human Tie-2


For use with catalog number DTE200
CtrlQC172 
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Proteome Profiler Mouse Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
ARY0147  
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY026 
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