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Tie-2: Products

Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.

Showing 1-10 out of 10 Tie-2 Products

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Human Magnetic Luminex Assay

LXSAHM62  
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Human Tie-2 Antibody

B/N, IHC, SW, WBAF31320  
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Human Tie-2 Quantikine ELISA Kit

ELISADTE20022  
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Human/Mouse Phospho-Tie-2 (Y992) Antibody

CyTOF-ready, Flow, WBAF272013  
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Mouse/Rat Tie-2 Antibody

B/N, WBAF76210  
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Recombinant Human Tie-2 Fc Chimera Protein, CF

Binding Activity313-TI12  
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Human Tie-2 PE-conjugated Antibody

FlowFAB3131P10  
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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B155  
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Human Tie-2 DuoSet ELISA

ELISADY515910  
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Proteome Profiler Mouse Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
ARY01420  
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