Toll-like Receptor Agonists: Products

TLRs make up a family of pattern recognition receptors that play important roles in the innate immune response. Broad classes of pathogens (e.g. viruses, bacteria, and fungi) constitutively express a set of mutation-resistant molecules called pathogen-associated molecular patterns (PAMPs). These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif. The TIR motif is common to the larger IL-1 R/TLR superfamily.

Showing 1-13 out of 13 Toll-like Receptor Agonists Products

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Poly(I:C)


TLR3 agonist
4287 
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Resiquimod


Toll-like receptor 7 (TLR7) agonist
4536 
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Pam3CSK4


TLR1/2 agonist; induces cytokine production
4633 
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Pam2CSK4


TLR2/6 agonist; induces TNF-alpha production
4637 
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Imiquimod


Toll-like receptor 7 (TLR7) agonist
3700 
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RWJ 21757


Toll-like receptor 7 (TLR7) agonist
2719 
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RS 09


TLR4 peptide agonist; acts as an adjuvant in vivo
5928 
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SM 324405


Potent TLR7 agonist
5445 
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CU-T12-9


Potent TLR1/2 agonist
5414 
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DSR 6434


Potent TLR7 agonist
4809 
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Pam3CSK4 Biotin


Biotinylated Pam3CSK4 (Cat. No. 4633)
4636 
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Pam2CSK4 Biotin


Biotinylated Pam2CSK4 (Cat. No. 4637)
4638 
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FSL 1


TLR2/6 agonist (also a putative TLR10 ligand)
6011 
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