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TrkA: Products

TrkA, the product of the protooncogene trk, is a member of the neurotrophic tyrosine kinase receptor family that has three members. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain.

Two distinct TrkA isoforms that differ by virtue of a 6 amino acid insertion in their extracellular domain have been identified. The longer TrkA isoform is the only isoform expressed within neuronal tissues whereas the shorter TrkA is expressed mainly in non neuronal tissues. NGF binds to TrkA with low affinity and activates its cytoplasmic kinase, initiating a signaling cascade that mediates neuronal survival and differentiation. Higher affinity binding of NGF requires the coexpression of TrkA with the p75 NGF receptor (NGFR), a member of the tumor necrosis factor receptor superfamily. NGFR binds all neurotrophins with low affinity and modulates Trk activity as well as alters the specificity of Trk receptors for their ligands. NGFR can also mediate cell death when expressed independent of Trk.

Showing 1-30 out of 30 TrkA Products

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Human TrkA Antibody

B/N, CyTOF-ready, Flow, IHC, WBAF1755  
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Recombinant Human TrkA Fc Chimera Protein, CF

 175-TK6  
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Rat TrkA Antibody

IHC, WBAF10565  
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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B135  
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Human/Rat Phospho-TrkA (Y785) Antibody

WBAF54792  
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Recombinant Rat TrkA Fc Chimera Protein, CF

 1056-TK2  
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Human TrkA APC-conjugated Antibody

FlowFAB1751A2  
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Human TrkA PE-conjugated Antibody

FlowFAB1751P1  
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GNF 5837


Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
4559 
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Rat TrkA Biotinylated Antibody

IHC, WBBAF1056 
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Rat TrkA Antibody

WBMAB10561  
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Human TrkA Antibody

WBMAB1751  
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GW 441756


Potent, selective TrkA inhibitor
22383  
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Human Phospho-TrkA DuoSet IC ELISA

ELISADYC2578-2 
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Human TrkA Alexa Fluor® 488-conjugated Antibody

FlowFAB1751G 
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Human TrkA Alexa Fluor® 700-conjugated Antibody

FlowFAB1751N 
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Ro 08-2750


Inhibits NGF binding to p75NTR and TrkA
2272 
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AG 879


TrkA inhibitor
2617 
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Lestaurtinib


JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
33952  
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PD 90780


Inhibits NGF binding to p75NTR
5101 
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Human Total TrkA DuoSet IC ELISA

ELISADYC175-2 
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Human TrkA (NP_002520) VersaClone cDNA

RDC0916 
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Rat TrkA (NP_067600) VersaClone cDNA

RDC0969 
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Human TrkA Alexa Fluor® 647-conjugated Antibody

FlowFAB1751R 
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Human TrkA Alexa Fluor® 750-conjugated Antibody

FlowFAB1751S 
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Human TrkA Alexa Fluor® 594-conjugated Antibody

FlowFAB1751T 
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Human TrkA Alexa Fluor® 350-conjugated Antibody

FlowFAB1751U 
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Human TrkA Alexa Fluor® 405-conjugated Antibody

FlowFAB1751V 
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Proteome Profiler Mouse Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
ARY01417  
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Proteome Profiler Human Ubiquitin Array


Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
ARY027 
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