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TrkA: Products

TrkA, the product of the protooncogene trk, is a member of the neurotrophic tyrosine kinase receptor family that has three members. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain.

Two distinct TrkA isoforms that differ by virtue of a 6 amino acid insertion in their extracellular domain have been identified. The longer TrkA isoform is the only isoform expressed within neuronal tissues whereas the shorter TrkA is expressed mainly in non neuronal tissues. NGF binds to TrkA with low affinity and activates its cytoplasmic kinase, initiating a signaling cascade that mediates neuronal survival and differentiation. Higher affinity binding of NGF requires the coexpression of TrkA with the p75 NGF receptor (NGFR), a member of the tumor necrosis factor receptor superfamily. NGFR binds all neurotrophins with low affinity and modulates Trk activity as well as alters the specificity of Trk receptors for their ligands. NGFR can also mediate cell death when expressed independent of Trk.

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Human TrkA Antibody

(1 Review)
4 Citations
Clonality: Polyclonal
Host: Goat IgG
Applications: B/N, Flow, IHC, WB
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AF175

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Human TrkA Antibody Neutralization

Rat TrkA Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: IHC, WB
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AF1056

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Rat TrkA Antibody Western Blot
Rat TrkA Antibody Immunohistochemistry

Human/Rat Phospho-TrkA (Y785) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: WB
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AF5479

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Human/Rat Phospho-TrkA (Y785) Antibody Western Blot

Rat TrkA Antibody

Clonality: Monoclonal
Host: Mouse IgG2b Clone #315104
Applications: WB
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MAB1056

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Human TrkA Antibody

Clonality: Monoclonal
Host: Mouse IgG2a Clone #165126
Applications: WB
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MAB175

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Human TrkA Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #165131
Applications: Flow
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MAB1751

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Human TrkA PE‑conjugated Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #165131
Applications: Flow
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FAB1751P

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Human TrkA PE‑conjugated Antibody Flow Cytometry

Human TrkA APC‑conjugated Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #165131
Applications: Flow
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FAB1751A

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Human TrkA APC‑conjugated Antibody Flow Cytometry

Rat TrkA Biotinylated Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: IHC, WB
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BAF1056

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Human TrkA Alexa Fluor® 700-conjugated Antibody

Clonality: Monoclonal
Host: Mouse Clone #165131
Applications: Flow
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FAB1751N

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