TrkA: Products

TrkA, the product of the protooncogene trk, is a member of the neurotrophic tyrosine kinase receptor family that has three members. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain.

Two distinct TrkA isoforms that differ by virtue of a 6 amino acid insertion in their extracellular domain have been identified. The longer TrkA isoform is the only isoform expressed within neuronal tissues whereas the shorter TrkA is expressed mainly in non neuronal tissues. NGF binds to TrkA with low affinity and activates its cytoplasmic kinase, initiating a signaling cascade that mediates neuronal survival and differentiation. Higher affinity binding of NGF requires the coexpression of TrkA with the p75 NGF receptor (NGFR), a member of the tumor necrosis factor receptor superfamily. NGFR binds all neurotrophins with low affinity and modulates Trk activity as well as alters the specificity of Trk receptors for their ligands. NGFR can also mediate cell death when expressed independent of Trk.

Showing 1-15 out of 15 TrkA Products

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Human TrkA Antibody

B/N, CyTOF-ready, Flow, IHC, WBAF1755  
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Rat TrkA Antibody

IHC, WBAF10565  
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Human/Rat Phospho-TrkA (Y785) Antibody

WBAF54792  
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Human TrkA PE-conjugated Antibody

FlowFAB1751P1  
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Rat TrkA Biotinylated Antibody

IHC, WBBAF1056 
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Human TrkA APC-conjugated Antibody

FlowFAB1751A1  
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Rat TrkA Antibody

WBMAB10561  
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Human TrkA Antibody

WBMAB1751  
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Human TrkA Alexa Fluor® 488-conjugated Antibody

FlowFAB1751G 
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Human TrkA Alexa Fluor® 700-conjugated Antibody

FlowFAB1751N 
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Human TrkA Alexa Fluor® 647-conjugated Antibody

FlowFAB1751R 
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Human TrkA Alexa Fluor® 750-conjugated Antibody

FlowFAB1751S 
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Human TrkA Alexa Fluor® 594-conjugated Antibody

FlowFAB1751T 
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Human TrkA Alexa Fluor® 350-conjugated Antibody

FlowFAB1751U 
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Human TrkA Alexa Fluor® 405-conjugated Antibody

FlowFAB1751V 
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