Twist-1: Products

Twist-1 (Twist-related protein 1; also H-Twist and bHLHa38) is a 25-27 kDa class B member of the bHLH transcription factor family of proteins. It is widely expressed in embryo, and select adult cells such as white adipocytes. In fat, Twist-1 induces fatty acid oxidation via PGC-1 alpha and CPT-1, and promotes MCP-1 and TNF-alpha secretion by adipocytes. In epithelium, Twist-1 dysregulation represses E-Cadherin and induces N-Cadherin expression, resulting in an epithelial-to-mesenchymal transition that can lead to cancer. Human Twist-1 is 202 amino acids (aa) in length. It contains a bHLH domain (aa 109-164) with an embedded DNA-binding motif. Twist-1 forms homodimers, and heterodimerizes with TCF3, HAND1 and HAND2. Two distinct mutations exist that may impact its dimerization pattern. There is one seven aa insertion after Ile135, and a second seven aa insertion after Pro139. A third unrelated variant shows a four Gly insert after Gly92. Full-length human Twist-1 shares 98% aa identity with mouse Twist-1.

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Human Twist-1 Antibody

Flow, ICC/IFAF62301  
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Human Twist-1 Antibody

Flow, WBMAB6230 
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Human Twist-1 Antibody

WBAF62301 
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Human Twist-1 Alexa Fluor® 647-conjugated Antibody

FlowIC9160R 
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Human Twist-1 PE-conjugated Antibody

FlowIC9160P 
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Human Twist-1 Fluorescein-conjugated Antibody

FlowIC6230F 
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Human Twist-1 Alexa Fluor® 488-conjugated Antibody

FlowIC9160G 
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Human Twist-1 APC-conjugated Antibody

FlowIC6230A 
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