UBE2N (Ubc13)/Uev1a Complex: Products

Ubiquitin-conjugating Enzyme E2N (UBE2N), also known as Ubiquitin-conjugating Enzyme 13 (Ubc13), forms a functional complex with the catalytically inactive Uev1a/UBE2V1 protein. Human UBE2N/Ubc13 shares 100% and 99% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. Human Uev1a/UBE2V1 shares 89% aa sequence identity with its mouse and rat orthologs. The UBE2N (Ubc13)/Uev1a Complex functions with Ubiquitin ligases (E3s), including TRAF-6 and TRIM5, to synthesize Lys63-linked Ubiquitin chains. These Ubiquitin chains can either be unanchored or attached to target proteins. The UBE2N (Ubc13)/Uev1a Complex localizes primarily to the cytoplasm and is important for NF-kappa B activation. Additionally, this complex may function in the intracellular response to retroviral capsid recognition. Pathologically, the UBE2N (Ubc13)/Uev1a Complex is required for the proliferation of diffuse large B-cell lymphoma cells, suggesting that it may play a role in cancer.

Showing 1-3 out of 3 UBE2N (Ubc13)/Uev1a Complex Products

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Recombinant Human His6-UBE2N (Ubc13)/Uev1a Complex, CF

 E2-6641  
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Recombinant Human UbcH (E2) Enzyme Set Protein


Contains 10 ug each of rhUbcH2/UBE2H, rhHis6-UbcH3/Cdc34, rhUbcH5a/UBE2D1, rhUbcH5b/UBE2D2, rhUbcH5c/UBE2D3, rhHis6-UbcH6/UBE2E1, rhUbcH7/UBE2L3, rhHis6-UBE2E3, rhUbcH10/UBE2C, and rhHis6-UbcH13/Uev1a Complex
K-980B 
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NSC 697923


Selective UBE2N inhibitor
4858 
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