UbcH10/UBE2C: Products

Ubiquitin-conjugating Enzyme H10 (UbcH10), also known as Ubiquitin-conjugating Enzyme E2C (UBE2C), is a 179 amino acid (aa) member of the yeast Ubc4/5 family of Ubiquitin-conjugating (E2) enzymes and has a predicted molecular weight of 20 kDa. Human UbcH10/UBE2C shares 96% aa sequence identity with mouse and rat UBE2C. UbcH10/UBE2C is an essential mediator of mitotic destruction events and cell cycle progression. UbcH10/UBE2C recognizes TEK sequences in target proteins such as Cyclins A and B, mediates Lys11-linked ubiquitination, and promotes target protein degradation in conjunction with APC/C, a Ubiquitin ligase (E3). The catalytic activity of UbcH10/UBE2C is regulated by a conserved N-terminal extension, which mediates E2-E3 interaction. UbcH10/UBE2C is overexpressed in a variety of human cancers, and alternate splice isoforms may contribute to uncontrolled cell proliferation and tumor progression.

Showing 1-5 out of 5 UbcH10/UBE2C Products

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Human UbcH10/UBE2C Antibody

WBA-6502  
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Recombinant Human UbcH (E2) Enzyme Set Protein


Contains 10 ug each of rhUbcH2/UBE2H, rhHis6-UbcH3/Cdc34, rhUbcH5a/UBE2D1, rhUbcH5b/UBE2D2, rhUbcH5c/UBE2D3, rhHis6-UbcH6/UBE2E1, rhUbcH7/UBE2L3, rhHis6-UBE2E3, rhUbcH10/UBE2C, and rhHis6-UbcH13/Uev1a Complex
K-980B 
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Recombinant Human UbcH10/UBE2C Protein, CF

 E2-654 
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Recombinant Human His6-UbcH10/UBE2C Protein, CF

 E2-650 
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Recombinant Human His6-UbcH10/UBE2C Dominant Negative, CF

 E2-652 
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