UbcH8: ProductsUbiquitin-conjugating Enzyme H8 (UbcH8), also known as Ubiquitin-conjugating Enzyme E2L 6 (UBE2L6), has a predicted molecular weight of 18 kDa. Human UbcH8 shares 76% and 74% amino acid sequence identity with mouse and rat UBE2L6, respectively. UbcH8 is capable of transferring either Ubiquitin or the Ubiquitin-like protein ISG15 Ubiquitin-like Modifier (ISG15) to target proteins. ISG15 conjugation is mediated by UbcH8 following IFN-alpha or IFN-beta stimulation. UbcH8 interacts with a variety of Ubiquitin ligases (E3s) to transfer Ubiquitin to target proteins such as the cell cycle regulator, p21/CIP1/CDKN1A. UbcH8 also regulates actin cytoskeleton dynamics, and dysregulated UbcH8 promotes migration and invasion of human breast cancer cells. In addition, UbcH8 interacts with the E3, Parkin, and is thought to play a role in the pathogenesis of Parkinsonâs disease.