Ubiquitin Ligase (E3) Inhibitors

Showing 1-26 out of 26 Ubiquitin Ligase (E3) Inhibitors Products

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proTAME


Cell-permeable APC/C inhibitor
I-4406  
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SZL P1-41


Selective Skp2 inhibitor; suppresses E3 ligase activity
5076 
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Heclin


HECT E3 ubiquitin ligase inhibitor
5433 
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RITA


MDM2-p53 interaction inhibitor
24431  
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Nutlin-3


MDM2 antagonist; inhibits MDM2-p53 interaction
39841  
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PRT 4165


Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
5047 
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Apcin


Cdc20 inhibitor; inhibits Cdc20-substrate interaction
5747 
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Apcin


Cell-permeable APC/C Inhibitor
I-444 
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NSC 66811


MDM2 antagonist. Disrupts MDM2-p53 interaction
2936 
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HLI 373


Hdm2 inhibitor; activates p53-dependent transcription
3503 
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SMER 3


Selective inhibitor of E3 ubiquitin ligase
4375 
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TAME hydrochloride


Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
45061  
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SKPin C1


Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
4817 
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NAB 2


Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
5131 
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PTC 209


Bmi-1 inhibitor; antitumor
5191 
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SP 141


High affinity MDM2 inhibitor
5332 
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A01


High affinity Smurf1 inhibitor; enhances BMP signaling
5397 
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GS 143


β-TrCP1 ligase inhibitor
5636 
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Nutlin 3a


MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
6075 
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MZ 1


(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells
6154 
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cis MZ 1


Negative Control for MZ1
6155 
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VH 298


High-affinity inhibitor of VHL
6156 
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cis VH 298


Negative control for VH 298
6157 
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Pomalidomide


Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic
6302 
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Lenalidomide


Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
6305 
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dBET1


(+)-JQ1 based PROTAC that selectively degrades BET bromodomains in cells
6327 
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