Uev1a/UBE2V1: Products

Ubiquitin-conjugating Enzyme Variant 1a (Uev1a), also known as Ubiquitin-conjugating Enzyme E2 Variant 1 (UBE2V1), is a member of the Ubiquitin-conjugating (E2) enzyme family. Human Uev1a/UBE2V1 and its mouse ortholog have predicted molecular weights of 19 kDa and 16.5 kDa, respectively. The human protein shares 89% amino acid (aa) sequence identity with its mouse ortholog. The E2 catalytic core domain of Uev1a/UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm Uev1a/UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. Uev1a/UBE2V1 is required for UBE2N (Ubc13)/Uev1a Complex-dependent Lys63-linked Ubiquitin chain formation. More specifically, Uev1a/UBE2V1 orients the Ubiquitin molecule to favor linkage at Lys63 via a non-covalent interaction with the Ubiquitin molecule. The human protein contains a non-conserved 30 aa N-terminal tail that functionally differentiates it from Mms2, another E2 enzyme variant and UBE2N/Ubc13 binding partner. Pharmacological inhibition of the UBE2N (Ubc13)/Uev1a Complex blocks the proliferation of diffuse large B-cell lymphoma cells, suggesting that this complex may play a role in cancer.

Showing 1-3 out of 3 Uev1a/UBE2V1 Products

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Recombinant Human UbcH (E2) Enzyme Set Protein


Contains 10 ug each of rhUbcH2/UBE2H, rhHis6-UbcH3/Cdc34, rhUbcH5a/UBE2D1, rhUbcH5b/UBE2D2, rhUbcH5c/UBE2D3, rhHis6-UbcH6/UBE2E1, rhUbcH7/UBE2L3, rhHis6-UBE2E3, rhUbcH10/UBE2C, and rhHis6-UbcH13/Uev1a Complex
K-980B 
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NSC 697923


Selective UBE2N inhibitor
4858 
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Recombinant Human His6-Uev1a (Mms2)/UBE2V1 Protein, CF

 E2-662 
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