VEGF R1/Flt-1: Products
VEGF R1 (vascular endothelial growth factor receptor 1; Flt-1) binds to VEGF-A, VEGF-B, and PlGF and functions in vasculogenesis, angiogenesis, lymphangiogenesis, and wound healing. It is expressed on endothelial cells, osteoblasts, placental trophoblasts, renal mesangial cells, and some hematopoietic stem cells. It can heterodimerize with VEGF R2 and modulate VEGF R2 mediated endothelial cell proliferation and vessel branching. VEGF R1 engagement on monocyte/macrophage lineage cells enhances their migration, and release of growth factors and cytokines.