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VEGF-D: Products

Vascular endothelia growth factor D (VEGF-D), also known as c-fos-induced growth factor (FIGF), is a secreted glycoprotein of the VEGF/PDGF family. VEGFs regulate angiogenesis and lymphangiogenesis during development and tumor growth, and are characterized by eight conserved cysteine residues that form a cystine knot structure. VEGF-C and VEGF-D, which share 23% amino acid (aa) sequence identity, are uniquely expressed as preproproteins that contain long N- and C-terminal propeptide extensions around the VEGF homology domain (VHD). Proteolytic processing of the 354 aa VEGF-D preproprotein creates a secreted proprotein. Further processing by extracellular serine proteases, such as plasmin or furin-like proprotein convertases, forms mature VEGF-D consisting of non-covalently linked 42 kDa homodimers of the 117 aa VHD.

Mature human VEGF-D shares 94%, 95%, 99%, 97% and 93% aa identity with mouse, rat, equine, canine and bovine VEGF-D, respectively. It is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs and skin. Mouse and human VEGF-D are ligands for VEGF receptor 3 (VEGF R3, also called Flt-4) that are active across species and show enhanced affinity when processed. Processed human VEGF-D is also a ligand for VEGF R2, also called Flk-1 or KDR. VEGF R3 is strongly expressed in lymphatic endothelial cells and is essential for regulation of the growth and differentiation of lymphatic endothelium. While VEGF-C is the critical ligand for VEGF R3 during embryonic lymphatic development, VEGF-D is most active in neonatal lymphatic maturation and bone growth. Both promote tumor lymphangiogenesis. Consonant with their activity on VEGF receptors, binding of VEGF-C and VEGF-D to neuropilins contributes to VEGF R3 signaling in lymphangiogenesis, while binding to integrin α9β1 mediates endothelial cell adhesion and migration.

Showing 1-20 out of 20 VEGF-D Products

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Human Magnetic Luminex Assay

LXSAHM8  
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Human VEGF-D Quantikine ELISA Kit

ELISADVED0020  
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Human Luminex Assay

LXSAH4  
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Human VEGF-D Antibody

B/N, IHC, WBAF2867  
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Human VEGF-D Antibody

B/N, IHCMAB2866  
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Recombinant Human VEGF-D Protein, CF

 622-VD/CF4  
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Recombinant Human VEGF-D Protein

 622-VD4  
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Mouse VEGF-D Antibody

IHC, WBAF4694  
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Human VEGF-D Antibody

ELISA(Cap), WBMAB28611  
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Mouse VEGF-D Antibody

ELISA(Cap), WBMAB4692  
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Human VEGF-D Biotinylated Antibody

ELISA(Det), WBBAM286 
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Recombinant Mouse VEGF-D Protein, CF

 469-VD/CF2  
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Recombinant Mouse VEGF-D Protein

 469-VD2  
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Mouse VEGF-D Biotinylated Antibody

ELISA(Det), WBBAF469 
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Human VEGF-D Antibody

WBMAB6221  
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Human VEGF-D DuoSet ELISA

ELISADY6222  
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Mouse VEGF-D DuoSet ELISA

ELISADY4691  
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Human VEGF-D Biotinylated Antibody

WBBAF286 
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Human VEGF-D Luminex Performance Assay

LAN622 
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Human VEGF-D Magnetic Luminex Performance Assay

LANM622 
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