VMAT2: Products

The vesicular monoamine transporter 2 (VMAT2; also known as VAT2 and SCL18A) is a 55 - 75 kDa member of the vesicular transporter family, a major facilitator superfamily. VMAT2 is a 12 transmembrane (TM) glycoprotein that is found in the membrane of brain neurosecretory vesicles. It transports monoamines (dopamine, serotonin, and particularly histamine) from the cytosol into secretion vesicles by exchanging two H+ ions for one molecule of amine.

Human VMAT2 is 514 amino acids (aa) in length. It contains a 20 aa and 52 aa N- and C-terminal cytoplasmic domain, plus an extended 88 aa luminal loop between aa 42 - 129. There is one luminal, intrachain disulfide bond that contributes to amine transport (C126 - C333). In addition, residues in TM domains 5 - 8 (aa 220 - 352) and 9 - 12 (aa 358 - 462) also contribute to high affinity ligand interaction. VMAT2 is constitutively phosphorylated by CKII on S511 and S513. Within the cytoplasmic C-terminus, human VMAT2 is 94% aa identical to rat VMAT2.

Showing 1-13 out of 13 VMAT2 Products

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Human VMAT2 Antibody

CyTOF-ready, Flow, IHC, WBMAB8327 
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Rose Bengal


Potent VGlut and VMAT inhibitor; cell permeable
5168 
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FFN 511


Fluorescent substrate for VMAT2
3878 
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FFN 206 dihydrochloride


Fluorescent VMAT2 substrate
5043 
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FFN 102 mesylate


Selective fluorescent substrate of DAT and VMAT2
5200 
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Human VMAT2 (NP_003045) VersaClone cDNA

RDC0481 
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Human VMAT2 Alexa Fluor® 488-conjugated Antibody

FlowFAB8327G 
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Human VMAT2 Alexa Fluor® 700-conjugated Antibody

FlowFAB8327N 
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Human VMAT2 Alexa Fluor® 647-conjugated Antibody

FlowFAB8327R 
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Human VMAT2 Alexa Fluor® 750-conjugated Antibody

FlowFAB8327S 
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Human VMAT2 Alexa Fluor® 594-conjugated Antibody

FlowFAB8327T 
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Human VMAT2 Alexa Fluor® 350-conjugated Antibody

FlowFAB8327U 
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Human VMAT2 Alexa Fluor® 405-conjugated Antibody

FlowFAB8327V 
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