Vitamin D3: Products

25-hydroxy-vitamin D3 (25(OH)D3) is synthesized in the liver and is the primary circulating form of vitamin D. Its blood concentration, which reflects 25(OH)D3 produced by exposure to ultraviolet B, as well as dietary and vitamin D supplementation, is felt to be the best indicator of vitamin D status. 25(OH)D3 is metabolized to 1-alpha,25(OH)2D3 in the proximal tubular cells of the kidney by the enzyme 1-alpha-hydroxylase. The vitamin D structure is similar to that of classic steroid hormones, such as estradiol, cortisol, and aldosterone in that they have the same root cyclopentanoperhydrophenanthrene ring structure. It has been shown that the active steroid hormone 1-alpha,25(OH)2D3 is essential for life in higher animals. Besides playing important roles in calcium homeostasis and bone mineral metabolism, it is now known to play a role in cellular differentiation, inhibition of cell growth, immune regulation and the prevention of neoplastic transformation. The active form of vitamin D3, 1-alpha,25(OH)2D3, acts both through its cellular receptor, the vitamin D receptor (VDR), and through other extrarenal targets in an autocrine and paracrine manner where 1-alpha-hydroxylase is present.

Showing 1-7 out of 7 Vitamin D3 Products

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Calcipotriol


Vitamin D3 analog
27001  
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Vitamin D3 Antibody

FlowMAB6566 
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Vitamin D3 Alexa Fluor® 488-conjugated Antibody

FlowIC6566G 
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Vitamin D3 APC-conjugated Antibody

FlowIC6566A 
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Alfacalcidol


Prodrug of vitamin D3 (Cat. No. 4156)
4159 
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22-Oxacalcitriol


Non-calcemic vitamin D3 (Cat. No. 4156) analog
4160 
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Tacalcitol


Synthetic vitamin D3 (Cat. No. 4156) analog
4157 
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