WIF-1: Products

WIF-1 (Wnt Inhibitory Factor 1) is a secreted protein that binds to Wnt proteins and inhibits their activity. In situ hybridization analysis in Xenopus laevis and zebrafish indicate that the message is highly expressed in presomitic mesoderm, the notochord, anterior regions of the brain, branchial arches, nasal placodes, and otic vescicles. WIF-1 inhibits secondary axis induction by Wnts and promotes secondary axis induction by Chordin in Xenopus embryos. In vitro, WIF-1 binds to Drosophila Wingless and Xenopus Wnt8 proteins. WIF-1 is implicated as an early event tumor suppressor in cancers of the prostate, breast, lung, and bladder, while in other cancer types, such as colon adenocarcinoma, WIF-1 facilitates tumorigenesis. WIF-1 is also expressed in mammalian retina and may play a role in photoreceptor development. The protein is synthesized as a 379 amino acid (aa) molecule that contains a signal sequence, a 150 aa WIF domain, 5 EGF-like repeats, and a hydrophilic domain at the carboxy terminus.

Showing 1-12 out of 12 WIF-1 Products

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Recombinant Human WIF-1 Protein, CF

 1341-WF/CF6  
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Recombinant Human WIF-1 Protein

 1341-WF6  
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Human WIF-1 Antibody

IHC, WBMAB1343  
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Human WIF-1 Antibody

WBAF1342  
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Human WIF-1 Biotinylated Antibody

ELISA(Det), WBBAM1341 
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Mouse WIF-1 Antibody

WBAF1351  
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Human WIF-1 Biotinylated Antibody

WBBAF134 
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Human WIF-1 Antibody

MAB1342 
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Mouse WIF-1 Biotinylated Antibody

WBBAF135 
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Mouse WIF-1 Antibody

WBMAB135 
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Human WIF-1 DuoSet ELISA

ELISADY134 
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Recombinant Mouse WIF-1 Protein, CF

 135-WF 
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